And men should know that from nothing else but from the brain come joys, laughter and jests, and sorrows, griefs, despondency and lamentations. And by this we acquire wisdom and knowledge, and we see and hear and know what are foul and what are fair, what sweet and what unsavory… and by the same organ we become mad and delirious and fears and terrors assail us

— Hippocrates (Greek physician 460-377 BC)

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